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Based on published research, several of the 20 genes display a connection to metastatic dissemination through their role in matrix degradation, migration, invasion and engraftment.
Cancer stem cells are a critical subpopulation of tumor cells that can drive tumor growth and resistance to therapy.1
The evaluation of “stemness” in patient tumors may have important implications for oncology treatment planning.2
Analysis of a serial cohort of patients from the IEO clinic in Milan demonstrated that StemPrintER can stratify breast cancer patients according to their risk of cancer recurrence.3
Analysis of StemPrintER in the TransATAC cohort demonstrated its prognostic utility: Patients with a SPRS Low result have significantly better outcomes than patients with a SPRS High result.4
References: 1) Zhao, et al. Cancer Transl Med. 2017 2) Pece, et al. Cell. 2010 3) Pece, et al. EBioMedicine. 2019 4) Pece, et al. Eur J Cancer. 2022 5) Boeri, et al. Proc Natl Acad Sci. 2011 6) Sozzi, et al. J Clin Oncol. 2014
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