Accustem Sciences Limited Accustem Sciences Limited is pleased to announce that the Forms 20-F and F-6 filed by Accustem Sciences Limited with the SEC were declared effective on 1 July 2021, enabling the completion of the in specie distribution and spin out of Accustem from Tiziana Life Sciences plc. The SEC filings can be viewed at https://sec.report/CIK/0001850767 and there is also a link to them on the Accustem website: www.accustem.com.

If you held ordinary shares in Tiziana Life Sciences plc (“Tiziana”) on the UK Record Date The timetable for the holders of Tiziana ordinary shares (traded on the London Stock Exchange) held in CREST and Certificated form is as follows: Demerger Record Time: 7:00 a.m. on 30 October 2020 Ex-entitlement date for Accustem Shares: 2 November 2020 CREST accounts credited with Accustem Shares: 8 July 2021* Certificates for Accustem Shares for those shareholders holding their Tiziana Life Sciences plc in certificated form: by 18 July 2021 * replacing allocation placeholders currently showing If you held Tiziana ADSs (traded on the US Nasdaq Market) on the DR Record Date The timetable for the holders of Tiziana ADSs (traded on the Nasdaq market) is set out below. You should also review the notice posted by JP Morgan, the ADR depositary bank, which can be found at https://www.adr.com/drprofile/88875G101 Announcement Tiziana CUSIP: 88875G101 Corporate Action Type: Spin Off with DR Distribution Spin Off Issuer Name: Accustem Sciences Limited Spin Off DR CUSIP: 00442Y101 DR Distribution Rate: 1 new Accustem DR(s) issued for every 1 existing Tiziana DR held on DR Record Date Tax Withholding Rate: n/a DR Record Date: November 6, 2020 DR Payment Date: July 14, 2021